Plenty of playoff contenders suddenly find themselves dealing with major injuries to notable players as the college football season reaches its halfway point.

Xavier Watts intercepted Caleb Williams twice and returned a fumble for a touchdown as No. 21 Notre Dame harassed the Heisman Trophy winner and handed No. 10 Southern California its first loss in a 48-20 victory.

Prince Kollie scored on a blocked punt, Benjamin Morrison returned an interception 96 yards for a touchdown and had another interception to set up another score as Notre Dame earned its second straight win over a ranked opponent, beating No. 5 Clemson 35-14.