Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42-34.

CeeDee Lamb had 122 yards from scrimmage, Tony Pollard had a 58-yard touchdown run and the Dallas defense produced timely sacks and turnovers in the Cowboys' 27-17 win over the New Orleans Saints.

Josh Allen passed for 260 yards and four touchdowns, Buffalo’s defense stifled New Orleans’ short-handed offense and the Bills rolled to a 31-6 victory that sent the injury-ravaged Saints to their fourth straight loss.

(AP Photo/Chris Szagola)In this strangest of NFL seasons in this weirdest of years, here's a matchup of division leaders you wouldn't expect: Seattle hosting the New York Giants. “If you win your division, you win your division,” Carroll says, and he knows: Seattle went 7-9 in 2010 and won the NFC West, then beat New Orleans in a playoff game. Patrick Mahomes has thrown for at least 300 yards seven times this season and has 22 straight games with at least one TD passing. New England has won the past five meetings, including a 2018 divisional playoff game. Chargers WR Keenan Allen leads the NFL with 85 receptions and has a TD catch in five straight games.

(AP Photo/Michael Conroy)Cleveland receiver Odell Beckham and Washington safety Landon Collins will have more tests Monday to determine the extent of what could be season-ending injuries. Beckham injured his left knee while attempting to make a tackle after Baker Mayfield threw an interception on the team's opening pass play. Collins injured his left ankle/Achilles tendon in noncontact fashion early in the second quarter. Phillips was carted off the field early in the second quarter. — Carolina left tackle Russell Okung (calf) left in the second half against New Orleans and did not return.