Supply chain issues are impacting businesses across the U.S. and the world -- but the impact has arguably been greater on small businesses.

LANSING, Mich. – Michigan officials said 11,900 doses of the Moderna COVID-19 vaccine the state was receiving are ruined and unusable. “That frustrates me when I know we are in a race and every vaccine matters, but that is not something I can control. Twenty-one shipments of the Moderna vaccine were rendered unusable because of temperature issues with the distributor. The distributor, McKesson Corporation, told the state the temperature went out of range and got too cold, affecting nearly 12-thousand doses. However, six additional shipments were also held back to make sure there were no issues with the vaccine.

Michigan Medicine is offering a live overview on efficacy, safety and what we know so far about COVID-19 vaccines. Emerging and infectious diseases specialist Dr. Sandro Cinti, who co-leads Michigan Medicine’s COVID-19 Vaccine and Therapeutics Task Force, will be giving updates on and taking questions. You can watch it live beginning at 3 p.m. Friday right here:

One day after the announcement that Pfizer has created a vaccine that’s 90% effective against COVID-19, a panel has broken people into four phases, based on priority, to determine when everyone would receive the vaccine. Although the Pfizer vaccine isn’t officially authorized for distribution, preparations are already underway across America to get it into people’s arms. That’s because this is a new type of vaccine that’s much more complicated and requires extra planning. Keep in mind that the Pfizer vaccine is only one of potentially several that will hopefully become available in the future. For example, Pfizer’s are spaced 21 days apart, while Moderna’s are spaced 28 days apart.

Researchers around the globe are working to create a safe and effective coronavirus (COVID-19) vaccine, but once that’s been accomplished, distributing that vaccine to the world’s population is going to be a massive challenge. Pfizer, in partnership with BioNTech, plans to make 100 million doses of its vaccine by the end of the year. “It really is working against the virus.”Meanwhile, companies such as UPS are preparing to pick up, store and deliver the vaccine. “A few months ago we started to get good information about what temperatures would be required for these vaccines,” Wheeler said. That’s not something people should be doing with COVID-19, so how to physically vaccine people will be another challenge after distribution.

STERLING HEIGHTS, Mich. Amazon is planning to open a new delivery center in Sterling Heights to help speed up deliveries in the area. Obviously Sterling Heights represents a significant customer base for Amazon, which certainly influenced their decision to select our city as the site for this delivery station, said Sterling Heights Mayor Michael Taylor. Our skilled labor in Southeast Michigan, particularly in Sterling Heights, is second to none. We are delighted Amazon has chosen Sterling Heights as home to one of the first delivery stations in the county.Delivery stations enable Amazon Logistics to supplement capacity and flexibility to Amazons delivery capabilities. Amazon says the delivery center will create hundreds of part-time and full-time jobs.