Matteo Berrettini has ended Andy Murray’s bid to return to the fourth round of a Grand Slam tournament by beating the the three-time major 6-4, 6-4, 6-7 (1), 6-3 at the U.S. Open.

Daria Snigur of Ukraine pulled off the first big upset of the U.S. Open, knocking off No. 7 seed Simona Halep 6-2, 0-6, 6-4.

Venus Williams lost to Canadian Rebecca Marino in her return to singles play after more than a year away.