He recently opened up about the side effects he had from the second dose so you know what to expect. Ask the doctor“My experience with the first dose of the Pfizer vaccine was pretty much in line with what I had expected. My second shot was a different story,” said McGeorge. Fortunately, he was able to reschedule his second dose to after his midnight shifts. I’m talking about this so you have an idea of what could happen after the second shot and are prepared.